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Accueil du site > Les équipes > Glycochimie Organique Biologique et Supramoléculaire (GOBS) > Thèmes de recherche > Mimes de sucres : azasugars, carbasugars

Mimes de sucres : azasugars, carbasugars

Analysis of the reaction coordinate of α–L fucosidases : a combined structural and quantum mechanical approach
J. Am. Chem. Soc., 2010, 132, 1804-1806

Molecular Basis for Inhibition of GH84 Glycoside Hydrolases by Substituted Azepanes : Conformational Flexibility Enables Probing of Substrate Distortion
J. Am. Chem. Soc., 2009, 131, 5390–5392

Design and synthesis of acetamido tri- and tetra-hydroxyazepanes : potent and selective β-N-acetylhexosaminidase inhibitors
Bioorg. Med. Chem. 2009, 17, 5598-5604

Hemi-Carbasucrose : Turning off exoanomeric effect induces less flexibility
Chem. Asian J. 2008, 3, 51-58

First Synthesis of 5-Fluoro-(+)-MK7607, its 1-Epimer and 6-Deoxy Derivative
Tetrahedron Lett., 2008, 49, 5548-5550

Transition-state mimicry in mannoside hydrolysis : characterisation of twenty-six inhibitors and insight into binding from linear free energy relationships and 3-D structure
Nat. Chem. Biol. 2008, 4, 306-312

New Synthetic Seven-Membered 1-Azasugars Displaying Potent Inhibition Towards Glycosidases and Glucosylceramide Transferase
ChemBioChem 2008, 9, 253-260

gem-Difluorocarbasugars, the cases of mannose and galactose
Carbohydr. Res. 2007, 342, 1689-1703

Tandem Staudinger–azaWittig mediated ring expansion : rapid access to new isofagomine-tetrahydroxyazepane hybrids
Chem. Commun., 2007, 183-185

The First Synthesis of gem-Difluoro-Carba-D-Glucose, a Step Further in Sugar Mimesis
Angew. Chem., Int. Ed. Engl., 2004, 43, 6680-6683

The first synthesis of substituted azepanes mimicking monosaccharides : a new class of potent glycosidase inhibitors
Org. Biomol. Chem., 2004, 2, 1492-1499

Trimethylaluminium (TMAL) promoted rearrangements of unsaturated sugars into cyclohexanes
Tetrahedron : Asymm., 2004, 15, 699-703

Cycloheptanic sugar mimetics, bridging the gap in the homologous series of carbocyclic analogues
Tetrahedron, 2002, 58, 10189-10196

From Glucose to Cyclooctanic Carba-glucose : a New Class of Carbohydrate Mimetics
Angew. Chem., Int. Ed. Engl., 2000, 39, 2466-2467

Carbocyclic Ring Closure of Unsaturated S-, Se- and C- Aryl Glycosides
Angew. Chem., Int. Ed. Engl., 2000, 39, 362-364